Product Overview
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is an engineered recombinant peptide analog optimized for high-stability biochemical research. By substituting glutamic acid with arginine at position 3 and incorporating a 13-amino-acid N-terminal extension, this molecule exhibits significantly reduced binding affinity to IGF-binding proteins (IGFBPs). This modification extends its biological half-life in vitro, providing researchers with the consistency required for cell culture and signal transduction pathway analysis.
Technical Specifications
To ensure experimental reproducibility and regulatory compliance, all lots undergo rigorous verification:
|
Parameter |
Specification |
|
Purity (HPLC) |
≥98.0% |
|
Molecular Weight (MS) |
7647.5 Da (±0.1% accuracy) |
|
Endotoxin Level |
<10 EU/mg (via LAL test) |
|
Synthesis Method |
Solid-Phase Peptide Synthesis (SPPS) |
|
Physical Appearance |
Lyophilized, white powder |
|
Storage Conditions |
−20 ∘ C (Long-term); Protected from light and moisture |
Key Technical Advantages
Performance Stability: Reduced IGFBP binding ensures the peptide maintains its bioactivity throughout prolonged experimental durations, minimizing the need for frequent media changes or compound re-dosing.
Analytical Integrity: Our synthesis process employs multi-stage reverse-phase HPLC purification to ensure high sequence fidelity. Every production lot is delivered with comprehensive analytical documentation.
Batch-to-Batch Reliability: Standardized manufacturing SOPs and automated systems ensure high molecular consistency, allowing research facilities to maintain long-term inventory without the risk of performance drift.
Manufacturing Capability: We operate automated, scalable SPPS and purification lines, enabling seamless transitions from pilot-scale research quantities to bulk supply for distributors.
B2B Supply & Logistics
We provide end-to-end support for global research institutions and commercial suppliers:
Cold Chain Assurance: All shipments are dispatched via medical-grade cold chain packaging (dry ice) to preserve structural integrity from our facility to your laboratory.
Customization (OEM/ODM): We offer private labeling, tailored vial quantities (e.g., 1mg/vial, 100μg/vial), and bespoke packaging configurations to meet your distribution branding.
Full Transparency: Each shipment includes the Certificate of Analysis (COA), HPLC chromatograms, and MS reports. We support your internal due diligence by providing these documents for audit purposes prior to order finalization.
International Compliance: Comprehensive documentation packages are provided for each shipment to ensure seamless customs clearance and maintain product potency.
Research Applications
This product is intended strictly for laboratory research use:
Signal Transduction: Studying kinase-mediated signaling and receptor activation pathways.
Cell Physiology: Evaluating cell proliferation and differentiation in defined media.
Biochemical Research: Analyzing protein-peptide interaction kinetics and structure-function relationships.
FAQ