Product Identification
IGF-1 DES is a high-purity synthetic variant of human Insulin-like Growth Factor-1. Through the site-specific deletion of the N-terminal tripeptide sequence (Gly-Pro-Glu), this peptide exhibits altered receptor binding kinetics compared to the native 70-amino acid IGF-1. It is engineered for specialized applications in peptide signaling, receptor-ligand interaction mapping, and kinetic studies of growth factor pathways.
Technical Specifications
|
Feature |
Specification |
|
Peptide Type |
Growth factor peptide variant |
|
Modification |
N-terminal Gly-Pro-Glu deletion |
|
Appearance |
White or off-white lyophilized powder |
|
Purity (HPLC) |
≥95% |
|
Identity (MS) |
Confirmed by Mass Spectrometry (MS) |
|
Storage Conditions |
-20°C or below (avoid repeated freeze-thaw) |
Synthesis & Manufacturing Protocol
Manufacturing is executed under an ISO-certified Quality Management System (QMS) to ensure product reliability for global research.
Synthesis: Fmoc-based solid-phase peptide synthesis (SPPS) is utilized to ensure precise sequence formation.
Purification: Multi-stage reverse-phase HPLC (RP-HPLC) with optimized acetonitrile/water/TFA gradients is employed to isolate the target peptide and remove truncated sequences or synthesis-related impurities.
Batch Consistency: Standardized synthesis protocols are maintained to ensure uniformity across production cycles. Each batch undergoes rigorous in-process monitoring of coupling efficiency and final product testing.
Quality Documentation
Every shipment is accompanied by a comprehensive Certificate of Analysis (COA) for total transparency. Documentation includes:
HPLC Chromatogram: Verification of final product purity.
Mass Spectrometry (MS) Report: Confirmation of molecular identity.
QA Guarantee: Any batch failing to meet the provided specifications is eligible for immediate technical support or replacement.
Research Applications
IGF Signaling Pathways: Utilized as a high-fidelity ligand to investigate receptor affinity and downstream intracellular signaling cascades.
Cell Biology: Applied in studies of cellular communication, mitogenic response, and growth factor molecular pathway analysis.
Structure-Activity Studies: Serves as a standard for benchmarking the influence of N-terminal modification on biological receptor binding properties.
B2B Supply & Logistics
We provide end-to-end support for international research facilities and industrial partners.
Supply Scale: Capability to support milligram-scale research orders, kilogram-scale bulk industrial supply, and recurring purchasing programs.
Customization: OEM and private labeling services available, including customized vial formatting and branded documentation support.
Cold-Chain Logistics: International transit utilizes thermally insulated, moisture-free packaging. Active cooling protocols (refrigerated gel packs/dry ice) are implemented to ensure product integrity, with real-time temperature monitoring options available for large-scale shipments.
FAQ