Custom Peptide Synthesis: From Sequence Design to Industrial Scale
We serve as a dedicated technical partner for pharmaceutical research, biotechnology, diagnostic assay development, and vaccine production. We specialize in the synthesis of custom peptides ranging from 2 to 80 amino acids, integrating advanced Solid-Phase Peptide Synthesis (SPPS) with rigorous analytical validation to ensure high sequence accuracy and batch-to-batch consistency.
Core Processes and Quality Control
Our manufacturing philosophy is built on technical precision, process transparency, and strict adherence to international quality standards:
Synthesis Strategy: We perform a pre-synthesis feasibility evaluation for every sequence. Depending on the sequence characteristics (e.g., hydrophobicity, aggregation propensity, or charge), we dynamically adjust deprotection protocols and coupling reagent ratios. For long or complex sequences, we utilize microwave-assisted synthesis or fragment condensation strategies to minimize deletion products and ensure structural integrity.
Purification and Validation: We utilize preparative HPLC to remove truncated sequences and deletion products. Every batch undergoes mandatory validation via LC-MS or MALDI-TOF MS to confirm molecular weight and sequence accuracy.
Batch Consistency: Our standardized operating procedures (SOPs) and robust quality management systems ensure that performance remains consistent from milligram-scale screening quantities to kilogram-scale production.
Specifications and Customization
|
Feature |
Specification / Capability |
|
Purity Levels |
Crude, ≥70%, ≥80%, ≥90%, ≥95%, ≥98%, ≥99% (upon request) |
|
Sequence Length |
2–80 amino acids (Routine; fragment condensation for longer) |
|
Scale |
Milligram (screening) to Kilogram (commercial production) |
|
Analysis Method |
Preparative HPLC purification; LC-MS / MALDI-TOF MS verification |
|
Documentation |
CoA, HPLC, and MS reports provided with every shipment |
Modification and Labeling Capabilities
Beyond linear sequences, we support a wide range of structural and chemical modifications:
Structural: Cyclic, stapled (upon evaluation), and multi-disulfide bond formation.
Labeling & Chemistry: Fluorescent tags (e.g., FITC), Biotin, PEG/PEGylation, Isotope labeling, Phosphorylation, Acetylation, and Amidation.
Full Lifecycle Research Support
We act as a technical partner, supporting your projects from the discovery phase through to large-scale clinical supply:
Fast Turnaround: 7–10 business days for standard peptides; 10–15 business days for modified peptides; custom manufacturing plans provided upon inquiry for bulk or complex projects.
Research Problem-Solving:
Poor Purity: High-performance HPLC purification for reliable biological outcomes.
Inconsistent Results: Validated procedures ensure long-term reproducibility.
Complex Sequences: Expert pre-synthesis evaluation optimizes success rates.
Documentation Gaps: Comprehensive analytical reports simplify your internal quality review.
FAQ